This core provides our experience with tape-capture of intact frozen sections of mineralized tissues followed by whole section imaging of the fluorescent and chromogenic signal emanating from the sections. It has proven useful in imaging the accumulated mineral, fluorescent mineralization lines, AP and TRAP positive cells, and GFP and immunofluorescent signals all from the same section. The histological approach has proven to be valuable for interpreting injury/repair and transplantation models of skeletal tissues (long bone, calvaria, knee, TMJ and teeth) and computer-controlled high throughput trabecular bone histomorphometry. These techniques can be contracted through the core and we offer hands-on training to laboratories that what to implement the methods.