The ECTS Working Group meetings began at ECTS Annual Congress several years ago, to provide a forum for focused discussion of specific issues in bone and mineral metabolism. 

The session will engage both basic scientists and clinical researchers. The exact Programme of the Working Group Day will be confirmed soon, but it will allow participation to multiple sessions.

 

Working Group 1: Non-Mammalian Models: the study of common and rare skeletal diseases

Zebrafish and mouse: Two useful models to study skull development Emilie Dambroise France
Zebrafish as model for human warfarin embryopathy Ignacio Fernandez Spain
Cell Plasticity During Bone Regeneration in Zebrafish Caudal Fins Antonio Jacinto Portugal
Loss of lysosomal enzymatic function and its implication in impaired bone homeostasis Enrico Moro Italy

 

 

Working Group 2: Rheumatic Diseases and Bone – Ankylosing Spondylitis and Bone

Introduction Willem Lems Netherlands
Drug-prevention of syndesmofytes in ankylosing spondylitis Andrea Giusti Italy
Modern imaging in ankylosing spondylitis Judith Haschka Austria
Pathophysiology of bone involvement in ankylosing spondylitis Corinne Miceli-Richard France
Closing remarks Christian Roux France

 

 

Working Group 3: Cancer and Bone –  Prostate Cancer (Jointly organised with CABS)

Androgen deprivation treatment: pros and cons in prostate cancer patients Francesco Bertoldo Italy
Bone health of men with prostate cancer – current treatments Daniele Santini Italy
Mechanisms underlying prostate cancer bone metastasis identified by big data analyses Yuuki Imai Japan

 

 

Working Group 4: Rare Bone Diseases – Rare Disorders with Bone Fragility and Mineralization Abnormalities

Mechanisms of bone fragility Wolfgang Högler Austria
Ancient rare bone diseases Gerhard Hotz Switzerland
Hypophosphatemia and mineralization disorders Ralf Oheim Germany
Genetic causes and therapies of OI Frank Zaucke Germany

 

 

Working Group 5: Mammalian Models – Focus on Bone and Metabolism and Bone Marrow Adiposity

Bone-related animal models Naomi Dirckx United States
Investigating the role of Gsa in the bone/marrow microenvironment through transgenic mouse models Mara Riminucci Italy
Experimental animal models to study cell metabolism in bone and muscle Marco Sandri Italy

 

 

Working Group 6: Osteoclasts – More than Resorption of Bone

Osteoclast shape, size and fusion: Lessons from a mouse model for SNX10-related osteopetrosis Ari Elson Israel
Osteoclasts, a major driver of inflammation Claudine Blin France
Osteoclasts in bone metastasis, player and target Nadia Rucci Italy

 

 

Working Group 7: Epigenetics and Bone Homeostasis

Transcriptional control and epigenetics of osteo versus adipo lineage progression Alexander Rauch Denmark
The epigenetic basis of vitamin C in bone formation Roman Thaler United States
MicroRNA control of bone remodelling and osteosarcopenia Hanna Taipaleenmaeki Germany

 

 

Working Group 8: Cartilage Pathophysiology

Proof of concept of a gene therapy approach for type II collagenopathies Elvire Gouze France
Chondrocyte fate, a new player: Lin28a Eric Hay France
Hypochondroplasia: Lessons from mouse model Laurence Legeai-Mallet France
Growth plate cartilage transplanted to the articular surface remodels into articular-like cartilage in a process promoted by the synovial joint microenvironment Zelong Dou, Stockholm
Temporal changes in subchondral bone and cartilage in a post-traumatic osteoarthritis rabbit model Lingwei Huang, Kuopio, Finland

 

 

Working Group 9: ERN-BOND

Future activities and opportunities:  Patient organisations engagement – presentation of quality of life study Ines Alves, Portugal
Future activities and opportunities: Guidelines Luca Sangiorgi Italy
Diagnostic challenges Valerie Cormier-Daire France
Rare bone disease classification study: Update and creation of the previous nosology Geert Mortier Belgium